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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1535313
Cathepsin B induces kidney diseases through different types of programmed cell death
Provisionally accepted
Yunlong Zhao 1,2,3
Yong Zhuang 1,2,3 Jie Shi 1,2,3 Haojun Fan 1,2,3*
Qi Lv 1,2,3* Xiaoqin Guo 1,2,3*- 1 Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China
- 2 Key Laboratory for Disaster Medicine Technology, Tianjin, China
- 3 Tianjin University, Wenzhou Safety (Emergency) Institute, Wenzhou, Zhejiang Province, China
Cathepsin B (CTSB), a key cysteine protease, plays essential roles in physiological and pathological processes. As research progresses, interest in how CTSB triggers different types of programmed cell death (PCD) to induce the onset and development of diseases is increasing. Several recent studies suggest that different types of PCD mediated by CTSB play key roles in kidney diseases. In this review, we outline the fundamental mechanisms by which CTSB triggers different types of PCD in several kidney diseases and discuss the function of CTSB in various segments of the kidney. Moreover, we explore the possibilities and prospects of using CTSB as a therapeutic target for kidney diseases.
Keywords: Cathepsin B, kidney disease, programmed cell death, Mechanism, Therapeutic target
Received: 27 Nov 2024; Accepted: 25 Feb 2025.
Copyright: © 2025 Zhao, Zhuang, Shi, Fan, Lv and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haojun Fan, Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China
Qi Lv, Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China
Xiaoqin Guo, Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China
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