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REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1534926
This article is part of the Research Topic Crosstalk in Ferroptosis, Immunity & Inflammation View all 22 articles
Intricating Connections: The Role of Ferroptosis in Systemic Lupus Erythematosus (SLE)
Provisionally accepted
Guowang Zhao 1
Xinghai Li 2* Ying Zhang 3* Xingzi Wang 4* Li Deng 5* Juan Xu 3* Shumei Jin 6*
Zan Zuo 3 Linting Xun 3* Mei Luo 3*
Yang Fan 7*
Qi Jialong 8* Ping Fu 1*- 1 Department of Rheumatology and Clinical Immunology, The Second Affiliated Hospital of Kunming Medical University, kunming, China
- 2 Department of Minimal Invasive Intervention Radiology, Ganzhou People's Hospital, Ganzhou, China
- 3 Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, kunming, China
- 4 Department of Nephrology, Yueyang Central Hospital, Yueyang, China
- 5 Community Health Service Station of Dian Mian Avenue, Heilinpu, Wuhua District, Kunming, China
- 6 Yunnan Institute of Food and Drug Supervision and Control, Medical Products Administration of Yunnan Province, Kunming, China
- 7 School of Medicine, Kunming University of Science and Technology, Kunming, China
- 8 Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China
Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease with multiple tissue damage. However, the pathology remains elusive, and effective treatments are lacking. Multiple types of programmed cell death (PCD) implicated in SLE progression have recently been identified. Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected. Therefore, this review elucidates the potential intricate relationship between SLE and ferroptosis to provide a reliable theoretical basis for further research on ferroptosis in the pathogenesis of SLE.
Keywords: systemic lupus erythematosus (SLE), ferroptosis, Interferons (IFNs), mitochondrial, damage-associated molecular patterns (DAMPs)
Received: 26 Nov 2024; Accepted: 17 Jan 2025.
Copyright: © 2025 Zhao, Li, Zhang, Wang, Deng, Xu, Jin, Zuo, Xun, Luo, Fan, Jialong and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinghai Li, Department of Minimal Invasive Intervention Radiology, Ganzhou People's Hospital, Ganzhou, China
Ying Zhang, Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, kunming, China
Xingzi Wang, Department of Nephrology, Yueyang Central Hospital, Yueyang, China
Li Deng, Community Health Service Station of Dian Mian Avenue, Heilinpu, Wuhua District, Kunming, China
Juan Xu, Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, kunming, China
Shumei Jin, Yunnan Institute of Food and Drug Supervision and Control, Medical Products Administration of Yunnan Province, Kunming, China
Linting Xun, Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, kunming, China
Mei Luo, Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, kunming, China
Yang Fan, School of Medicine, Kunming University of Science and Technology, Kunming, China
Qi Jialong, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China
Ping Fu, Department of Rheumatology and Clinical Immunology, The Second Affiliated Hospital of Kunming Medical University, kunming, China
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