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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1534263
This article is part of the Research Topic The Crosstalk Between Metabolism and Inflammation in Aging and Longevity View all articles

Cellular Senescence: from homeostasis to pathological implications and therapeutic strategies

Provisionally accepted
Chunhong Li Chunhong Li 1Yixiao Yuan Yixiao Yuan 2Yingdong Jia Yingdong Jia 1Qiang Zhou Qiang Zhou 1Qiang Wang Qiang Wang 1Xiulin Jiang Xiulin Jiang 2*
  • 1 Suining Central Hospital, Suining, China
  • 2 University of Florida, Gainesville, United States

The final, formatted version of the article will be published soon.

    Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence and cancer is complex and multifaceted, senescence can both promote and inhibit tumor progression through various mechanisms. M6A methylation modification regulates the aging process of cells and tissues by modulating senescence-related genes. In this review, we comprehensively discuss the characteristics of cellular senescence, the signaling pathways regulating senescence, the biomarkers of senescence, and the mechanisms of anti-senescence drugs. Notably, this review also delves into the complex interactions between senescence and cancer, emphasizing the dual role of the senescent microenvironment in tumor initiation, progression, and treatment.Finally, we thoroughly explore the function and mechanism of m6A methylation modification in cellular senescence, revealing its critical role in regulating gene expression and maintaining cellular homeostasis. In conclusion, this review provides a comprehensive perspective on the molecular mechanisms and biological significance of cellular senescence and offers new insights for the development of anti-senescence strategies.

    Keywords: cellular senescence, Cancer, M6A RNA methylation, Aging, Longevity, Inflammation

    Received: 25 Nov 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Li, Yuan, Jia, Zhou, Wang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiulin Jiang, University of Florida, Gainesville, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.