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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Viral Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1533102
This article is part of the Research Topic SARS-CoV-2: Virology, Epidemiology, Diagnosis, Pathogenesis and Control, Volume II View all articles
Tracking the Evolution of Serum Antibody Levels and Influencing Factors Post-SARS-CoV-2 Infection among Community Residents in Fuzhou City
Provisionally accepted- 1 The Affiliated Fuzhou Center for Disease Control and Prevention of Fujian Medical University, Fuzhou, China
- 2 School of Public Health, Fujian Medical University, Fuzhou, Fujian Province, China
Objective: To track the level of serum antibodies in Fuzhou residents and analyze the possible influencing factors of serum antibodies, so as to provide a scientific basis for the adjustment of population immunity and prevention and control strategies. Methods: Residents in the Fuzhou community who had symptoms of covid-19 infection or who had tested positive for nucleic acid or antigen since December 2022 were selected for the questionnaire survey and their sera were collected to analyze the trend of antibody changes, the antibody level was divided into high antibody group and low antibody group according to the literature data. The possible influencing factors of serum antibody level was analyzed by multivariate logistic regression model.Results: A total of 2,521 Fuzhou residents were adopted in the study, including 223 in the high antibody group and 194 in the low antibody group. A univariate analysis showed that, there were significant differences in age (Z=-4.028, P<0.00) , occupation ( 2 =18.591, P=0.005) , typical symptoms after the first infection ( 2 =9.784, P=0.002), history of surgery ( 2 =29.542, P<0.001), symptoms lasting more than 2 weeks after the first infection ( 2 =4.887, P=0.027), smoking ( 2 =18.524, P<0.001) and drinking ( 2 =19.578, P<0.001) between the high antibody group and the low antibody group.
Keywords: Conceptualization and methodology, Xiaoyang Zhang, writingoriginal draft preparation, Qingquan Chen and Xiaoyan Zheng, writingreview and editing, Qiangbing Liao, validation, Xiaoyan Zheng, formal analysis, Xiaoyan Zheng SARS-CoV-2, community residents, Serum antibody, Influencing factors
Received: 23 Nov 2024; Accepted: 12 Mar 2025.
Copyright: © 2025 Zheng, Chen, Liao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoyang Zhang, The Affiliated Fuzhou Center for Disease Control and Prevention of Fujian Medical University, Fuzhou, China
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