AUTHOR=Xie Shufeng , Long Jinlan , Wang Ruiheng , Xiang Rufang , Xian Huajian , Wang Yixin , Dou Weiyu , Zhang Wenjie , Li Dan , Kang Ting , Chen Zhihong , Zhao Chunjun , Xu Zhenshu , Liu Han TITLE=Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion JOURNAL=Frontiers in Immunology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1531344 DOI=10.3389/fimmu.2025.1531344 ISSN=1664-3224