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REVIEW article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1531068
This article is part of the Research Topic Community Series in Trends in Neuroimmunology: cross-talk between brain-resident and peripheral immune cells in both health and disease, volume II View all 6 articles

Immune conversations at the border: Meningeal immunity in health and disease

Provisionally accepted
Preya U Patel Preya U Patel 1Aryan Regmi Aryan Regmi 1Angelina Dass Angelina Dass 1Olga Lucia Rojas Olga Lucia Rojas 2*
  • 1 Department of Immunology, University of Toronto, Toronto, Ontario, Canada
  • 2 Krembil Research Institute, University Health Network (UHN), Toronto, Canada

The final, formatted version of the article will be published soon.

    The brain and spinal cord, collectively known as the central nervous system, are encapsulated by an overlapping series of membranes known as the meninges. Once considered primarily a physical barrier for central nervous system protection, the bordering meninges are now recognized as highly immunologically active. The meninges host diverse resident immune cells and serve as a critical interface with peripheral immunity, playing multifaceted roles in maintaining central nervous system homeostasis, responding to pathogenic threats, and neurological disorders. This review summarizes recent advancements in our understanding of meningeal immunity including its structural composition, physiological functions, and role in health and disease.

    Keywords: Meningeal anatomy, Meningeal immunity, Central Nervous System, Immune cells - Duramater, CNS diseases

    Received: 19 Nov 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Patel, Regmi, Dass and Rojas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Olga Lucia Rojas, Krembil Research Institute, University Health Network (UHN), Toronto, Canada

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.