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CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1529745
Treatment of pro-B Acute Lymphoblastic Leukemia and Severe Plaque Psoriasis with Anti-CD19 CAR T Cells: A Case Report
Provisionally accepted
Ao Zhang Guangji Zhang Huihui Yang 
Bengfa Gong Shouyun Li Na Wei Hui Xue 
Hui Wei 
Jianxiang Wang 
Shaowei Qiu *- Peking Union Medical College Hospital (CAMS), Beijing, China
We reported a rare case of pro-B acute adult lymphoblastic leukemia (pro-B ALL) accompanied by severe refractory plaque psoriasis treated with autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. An 18-year-old man was diagnosed of pro-B ALL with a known history of mild plaque psoriasis for 1 years. After induction chemotherapy, his psoriasis began to worsen. Extensive erythema and desquamation developed on the whole body with severe plaque psoriasis on the knees and elbows, which did not response to topical therapy. The application of CAR T-cell therapy not only enabled him to achieve deep complete remission (CR), but also allowed his skin lesions to completely subside. The successful treatment supports a potential pathogenic link between B cells and psoriasis which could provide a new option to overcome refractory psoriasis.
Keywords: pro-B ALL, Psoriasis, CD19 CAR T cells, B cell, therapeutic targets
Received: 17 Nov 2024; Accepted: 13 Feb 2025.
Copyright: © 2025 Zhang, Zhang, Yang, Gong, Li, Wei, Xue, Wei, Wang and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shaowei Qiu, Peking Union Medical College Hospital (CAMS), Beijing, China
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