AUTHOR=Ren Huili-li , Zhang Shao-hui , Li Pei-yuan TITLE=The multifaceted role of phosphodiesterase 4 in tumor: from tumorigenesis to immunotherapy JOURNAL=Frontiers in Immunology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1528932 DOI=10.3389/fimmu.2025.1528932 ISSN=1664-3224