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MINI REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1526961
This article is part of the Research Topic Ferroptosis and Cuproptosis: Unveiling Pathways and Translational Prospects View all 5 articles
Ferroptosis and Cuproptosis in Periodontitis: Recent Biological Insights and Therapeutic Advances
Provisionally accepted- 1 Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China
- 2 Affiliated Stomatological Hospital, Southern Medical University, Guangzhou, China
Periodontitis is a significant global public health issue associated with the onset and progression of various systemic diseases, thereby requiring additional research and clinical attention. Although ferroptosis and cuproptosis have emerged as significant areas of research in the medical field, their precise roles in the pathogenesis of periodontitis remain unclear. We aim to systematically summarize the current research on ferroptosis and cuproptosis in periodontal disease and investigate the roles of glutathione pathway and autophagy pathway in connecting ferroptosis and cuproptosis during periodontitis. Further, we propose that a homeostatic imbalance of copper and iron, driven by periodontal pathogens, may contribute to elevated periodontal oxidative stress, representing a potential unifying link between ferroptosis and cuproptosis involved in periodontitis. This article presents a comprehensive overview of the molecular mechanisms underlying ferroptosis and cuproptosis in periodontitis, offering novel theoretical insights into its pathogenesis and potential therapeutic targets.
Keywords: Periodontitis, ferroptosis, cuproptosis, Oxidative Stress, Glutathione, Autophagy
Received: 12 Nov 2024; Accepted: 05 Feb 2025.
Copyright: © 2025 Zheng, Lu, Wu, Chen, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tengyi Zheng, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China
Fumiao Lu, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China
Peihang Wu, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China
Yangan Chen, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China
Rongxin Zhang, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China
Xin Li, Affiliated Stomatological Hospital, Southern Medical University, Guangzhou, China
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