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MINI REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1526390
This article is part of the Research Topic Advances in Innate Immune Cells in chronic non-transmissible diseases: From Sensing to Effector Mechanisms in Inflammatory Diseases View all articles

Mitochondrial DNA in Atherosclerosis Research Progress: A Mini Review

Provisionally accepted
Zheng Liu Zheng Liu 1Nan Huang Nan Huang 1Chan Liu Chan Liu 2Can Wu Can Wu 1*Ling Zhou Ling Zhou 1*Xiang Liu Xiang Liu 1*Haibo Lei Haibo Lei 1*
  • 1 Xiangtan Central Hospital, Xiangtan, China
  • 2 Liuyang People's Hospital, Changsha, Hunan, China

The final, formatted version of the article will be published soon.

    Atherosclerosis (AS) is a chronic inflammatory disease that primarily affects large and medium-sized arteries and is one of the leading causes of death worldwide. This article reviews the multifaceted role of mitochondrial DNA (mtDNA) in AS, including its structure, function, release, and relationship with inflammation. Damage and release of mtDNA are considered central drivers in the development of AS, as they participate in the progression of AS by activating inflammatory pathways and affecting lipid metabolism. Therefore, therapeutic strategies targeting mtDNA and its downstream effects may provide new avenues to address this global health challenge.

    Keywords: mtDNA, Atherosclerosis, Mitochondria, Inflammation, Research progress

    Received: 11 Nov 2024; Accepted: 23 Jan 2025.

    Copyright: © 2025 Liu, Huang, Liu, Wu, Zhou, Liu and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Can Wu, Xiangtan Central Hospital, Xiangtan, China
    Ling Zhou, Xiangtan Central Hospital, Xiangtan, China
    Xiang Liu, Xiangtan Central Hospital, Xiangtan, China
    Haibo Lei, Xiangtan Central Hospital, Xiangtan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.