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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1526368
ETS-1 in Tumor Immunology: Implications for Novel Anti-Cancer Strategies
Provisionally accepted- 1 Anhui University of Traditional Chinese Medicine First Clinical Medical College, Anhui Hefei, China
- 2 First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China
- 3 Anhui University of Traditional Chinese Medicine Academic Affairs Office, Anhui Hefei, China
- 4 Anhui University of Chinese Medicine, Hefei, Anhui Province, China
ETS-1, a key member of the Erythroblast Transformation-Specific (ETS) transcription factor family, plays an important role in cell biology and medical research due to its wide expression profile and strong transcriptional regulation ability. It regulates fundamental biological processes, including cell proliferation, differentiation, and apoptosis, and is involved in tumorigenesis and metastasis, promoting malignant behaviors such as angiogenesis, matrix degradation, and cell migration. Given the association between ETS-1 overexpression and the aggressive characteristics of multiple malignancies, it represents a promising therapeutic target in cancer treatment. This study aims to systematically analyze the role of ETS-1 within the tumor immune microenvironment, elucidating its mechanisms in cancer initiation, progression, and metastasis. It also investigates the differential expression of ETS-1 across tumor tissues and adjacent normal tissues, exploring its potential as a molecular marker for tumor diagnosis and prognosis.
Keywords: Ets family, tumor immunology, ETS-1, biological functions, immune microenvironment, immunotherapy targets
Received: 11 Nov 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Wang, wan, zhang, fang, zhang, li and yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
lei wan, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China
xiaojun zhang, Anhui University of Traditional Chinese Medicine Academic Affairs Office, Anhui Hefei, China
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