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REVIEW article
Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1525948
This article is part of the Research Topic The chicken or egg conundrum: ‘Immune dysregulation and gut dysbiosis in aging’ View all 3 articles
Sexual Dimorphism in Immunity and Longevity among the Oldest Old
Provisionally accepted- Center for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia
Human longevity is a sex-biased process in which sex chromosomes and sex-specific immunity may play a crucial role in the health and lifespan disparities between men and women. Generally, women have a higher life expectancy than men, exhibiting lower infection rates for a broad range of pathogens, which results in a higher prevalence of female centenarians compared to males.Investigation of the immunological changes that occur during the process of healthy aging, while taking into account the differences between sexes, can significantly enhance our understanding of the mechanisms that underlie longevity. In this review, we aim to summarize the current knowledge on sexual dimorphism in the human immune system and gut microbiome during aging, with a particular focus on centenarians, based exclusively on human data.
Keywords: sexual dimorphism, Longevity, Sex-specific, centenarians, Aging, immune response
Received: 10 Nov 2024; Accepted: 28 Jan 2025.
Copyright: © 2025 Vasilevska, Arakelyan, Kupriyanova and Rogaev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Daria Kupriyanova, Center for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia
Evgeny Rogaev, Center for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia
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