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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1525567
The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease
Provisionally accepted- 1 Texas A and M University, College Station, United States
- 2 Houston Methodist Research Institute, Houston, Texas, United States
- 3 Weill Cornell Medicine, Cornell University, New York, New York, United States
S100A4 is a Ca 2+ -binding protein involved in multiple chronic inflammatory and neoplastic conditions. This review focuses on recent advances in the understanding of S100A4 function in immune cells, comparing and contrasting S100A4 regulation of immune responses in cancer and chronic inflammatory diseases. We provide evidence that S100A4 regulation of immune cell function has a profound role in promoting the pathogenesis of cancer and pro-inflammatory conditions. Finally, we discuss relevant future directions to target S100A4 therapeutically in different disease states.
Keywords: S100A4, FSP-1, immune suppression, Cancer, Fibrosis, chronic inflammation, Macrophages, T cells
Received: 09 Nov 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Wong, Kang and Yun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kyuson Yun, Houston Methodist Research Institute, Houston, 77030, Texas, United States
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