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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1524058
The role of efferocytosis in inflammatory bowel disease
Provisionally accepted- 1 Henan University of Chinese Medicine, Zhengzhou, China
- 2 First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Efferocytosis is the process by which various phagocytes clear apoptotic cells. In recent years, an increasing body of evidence has emphasized the importance of efferocytosis in maintaining internal homeostasis. Intestinal macrophages play a crucial role in modulating intestinal inflammation and promoting tissue repair. Inflammatory bowel disease (IBD) is a chronic, progressive, and relapsing condition, primarily marked by the presence of ulcers in the digestive tract. The exact mechanisms underlying IBD are not yet fully understood, and current treatment approaches mainly aim at repairing the damaged intestinal mucosa and reducing inflammatory responses to ease symptoms.This article provides new perspectives on IBD treatment and clinical management by examining the expression of macrophage efferocytosis-related molecules, the effects of efferocytosis on IBD development, the various roles of macrophage efferocytosis in IBD, and treatment strategies for IBD that focus on efferocytosis.
Keywords: Efferocytosis, inflammatory bowel disease, Macrophages, Intestinal Mucosal Repair, Inflammatory Response
Received: 07 Nov 2024; Accepted: 16 Jan 2025.
Copyright: © 2025 Liu, Li, Han and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yi-Qian Liu, Henan University of Chinese Medicine, Zhengzhou, China
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