AUTHOR=Yan Huanhuan , Zi Xiaoyu , Yan Huer , Zhang Xiaoying , Bai Jie , Gao Chong , Li Xiaofeng , Wang Caihong TITLE=The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2 JOURNAL=Frontiers in Immunology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1522893 DOI=10.3389/fimmu.2025.1522893 ISSN=1664-3224