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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1521388
This article is part of the Research Topic Deciphering Cell-Cell Interactions in Triple-Negative Breast Cancer View all articles
Analysis of single-cell and spatial transcriptomics in TNBC cell-cell interactions
Provisionally accepted- 1 Changchun University of Chinese Medicine, Changchun, Jilin Province, China
- 2 Jilin University, Changchun, China
Triple-negative breast cancer (TNBC) is a highly malignant tumor in women, characterized by high morbidity, mortality, and recurrence rates. Although surgical treatment, radiotherapy, and chemotherapy are the mainstays of current treatment methods, the high heterogeneity of TNBC results in unsatisfactory outcomes with low 5-year survival rates. Rapid advancements in omics technology have propelled the understanding of TNBC molecular biology. The emergence of single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) has significantly enhanced knowledge of tumor heterogeneity and the distribution, functionality, and intercellular interactions of various cell types within the tumor microenvironment, including tumor cells, T cells, B cells, macrophages, and fibroblasts. The present study provides an overview of the technical characteristics of scRNA-seq and ST, highlighting their applications in exploring TNBC heterogeneity, cell spatial distribution patterns, and intercellular interactions. This review aims to enhance the comprehension of TNBC at the cellular level for the development of effective therapeutic targets.
Keywords: TNBC, single-cell RNA sequencing, cell-cell interactions, Spatial transcriptome, St
Received: 01 Nov 2024; Accepted: 05 Feb 2025.
Copyright: © 2025 Xin, Ma, Deng, Wang, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yan Xin, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
Qiji Ma, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
Qiang Deng, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
Tielin Wang, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
Gang Wang, Changchun University of Chinese Medicine, Changchun, 130117, Jilin Province, China
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