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MINI REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1519998
This article is part of the Research Topic Exploring Immune-Stromal Cell Dynamics: Pathways and Therapeutic Implications View all articles

Epithelial-Mesenchymal Transition (EMT) in Asthma: Its Role and Underlying Regulatory Mechanisms

Provisionally accepted
Bingxi Zhang Bingxi Zhang 1*Xinru Feng Xinru Feng 1*Lincha Tian Lincha Tian 1*Bo Xiao Bo Xiao 2Lixia Hou Lixia Hou 2*Biwen Mo Biwen Mo 1*Dong Yao Dong Yao 1*
  • 1 The Second Affiliated Hospital of Guilin Medical University, Guilin, China
  • 2 Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Region, China

The final, formatted version of the article will be published soon.

    Bronchial asthma (asthma) is a respiratory disease characterized by chronic inflammation, airway hyperresponsiveness, and airway remodeling. Numerous studies have delved into asthma's pathogenesis, among which epithelial mesenchymal transition (EMT) is considered one of the important mechanisms in the pathogenesis of asthma. EMT refers to the transformation of epithelial cells, which lose their original features and acquire a migratory and invasive stromal phenotype.EMT contributes to normal physiological functions like growth, development, and wound healing.However, EMT is also involved in the occurrence and development of many diseases. Currently, the precise regulatory mechanism linking EMT and asthma remain obscure. Increasing evidence suggests that airway EMT contributes to asthma pathogenesis via dysregulation of associated control mechanisms. This review explores EMT's significance in asthma and the regulatory networks associated with EMT in this context.

    Keywords: Asthma, airway inflammation, Airway Remodeling, Epithelial-Mesenchymal Transition, Mechanism, Signaling Pathways

    Received: 30 Oct 2024; Accepted: 08 Jan 2025.

    Copyright: © 2025 Zhang, Feng, Tian, Xiao, Hou, Mo and Yao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bingxi Zhang, The Second Affiliated Hospital of Guilin Medical University, Guilin, China
    Xinru Feng, The Second Affiliated Hospital of Guilin Medical University, Guilin, China
    Lincha Tian, The Second Affiliated Hospital of Guilin Medical University, Guilin, China
    Lixia Hou, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Region, China
    Biwen Mo, The Second Affiliated Hospital of Guilin Medical University, Guilin, China
    Dong Yao, The Second Affiliated Hospital of Guilin Medical University, Guilin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.