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REVIEW article

Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1519925

The role of short-chain fatty acid in metabolic syndrome and its complications:focusing on immunity and inflammation

Provisionally accepted
Wenqian Yu Wenqian Yu 1,2*Siyuan Sun Siyuan Sun 1,3Qiang Fu Qiang Fu 1*
  • 1 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
  • 2 Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
  • 3 First Clinical Medical College, Beijing University of Chinese Medicine, beijing, China

The final, formatted version of the article will be published soon.

    Metabolic syndrome(Mets) is an important contributor to morbidity and mortality in cardiovascular, liver, neurological, and reproductive diseases. Short-chain fatty acid (SCFA), an organismal energy donor, has recently been demonstrated in an increasing number of studies to be an important molecule in ameliorating immuno-inflammation, an important causative factor of the Mets, and to improve lipid distribution, blood glucose, and body weight levels in animal models of the Mets. This study reviews recent research advances on SCFA in Mets from an immune-inflammatory perspective, including complications dominated by chronic inflammation, as well as the fact that these findings also contribute to the understanding of the specific mechanisms by which gut flora metabolites contribute to metabolic processes in humans. This review proposes an emerging role for SCFA in the inflammatory Mets, followed by the identification of major ambiguities to further understand the anti-inflammatory potential of this substance in the Mets. In addition, this study proposes novel strategies to modulate SCFA for the treatment of Mets that may help to mitigate the prognosis of Mets and its complications.

    Keywords: Short Chain Fatty Acids, metabolic syndrome, Inflammation, Immunity, complications 1.Introduction

    Received: 30 Oct 2024; Accepted: 09 Jan 2025.

    Copyright: © 2025 Yu, Sun and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wenqian Yu, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
    Qiang Fu, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.