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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1517495
This article is part of the Research Topic Cancer Metastases: Mechanisms of Tumor Dissemination, Formation of Metastatic Niche and Anti-metastatic Therapy View all 8 articles

Exosome tropism and various pathways in lung cancer metastasis

Provisionally accepted
Hui Chen Hui Chen 1Lin Liu Lin Liu 2Dan Zhang Dan Zhang 1Gang Xing Gang Xing 1Niumuqie A Niumuqie A 1*Yaling Li Yaling Li 3Ge Zhao Ge Zhao 3Minghua Liu Minghua Liu 1*
  • 1 Southwest Medical University, Luzhou, China
  • 2 The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China
  • 3 The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

The final, formatted version of the article will be published soon.

    Lung cancer, characterized by its high morbidity and mortality rates, has the capability to metastasize to various organs, thereby amplifying its detrimental impact and fatality.The metastasis of lung cancer is a complex biological phenomenon involving numerous physiological transformations. Exosomes, small membranous vesicles enriched with biologically active components, are pivotal in mediating intercellular communication and regulating physiological functions due to their specificity and stability. Extensive research has elucidated the production and functions of exosomes in cancer contexts.Multitude of evidence demonstrates a strong association between lung cancer metastasis and exosomes. Additionally, the concept of the pre-metastatic niche is crucial in the metastatic process facilitated by exosomes. This review emphasizes the role of exosomes in mediating lung cancer metastasis and their impact on the disease's development and the progression to other tissues. Furthermore, it explores the potential of exosomes as biomarkers for lung cancer metastasis, offering significant insights for future clinical advancements.

    Keywords: lung cancer, Exosomes, metastasis, biomarkers, Pre-metastatic niche

    Received: 26 Oct 2024; Accepted: 20 Jan 2025.

    Copyright: © 2025 Chen, Liu, Zhang, Xing, A, Li, Zhao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Niumuqie A, Southwest Medical University, Luzhou, China
    Minghua Liu, Southwest Medical University, Luzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.