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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1516473
This article is part of the Research Topic Immunology at the feto-maternal interface View all 20 articles
Epigenetic Regulation in Oogenesis and Fetal Development: Insights into m6A Modifications
Provisionally accepted- 1 Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
- 2 Ningbo Traditional Chinese Medicine Hospital, Ningbo, Zhejiang Province, China
- 3 Nanjing Tongren Hospital, Nanjing, Liaoning Province, China
The unique physiological structure of women has led to a variety of diseases that have attracted the attention of many people in recent years. Disturbances in the reproductive system microenvironment lead to the progression of various female tumours and pregnancy disorders. Numerous studies have shown that epigenetic modifications crucially influence both oogenesis and foetal development. m6A, a modification at the mRNA level, consists of three parts, namely, writers, erasers, and readers, which are involved in several biological functions, such as the nucleation and stabilization of mRNAs, thereby regulating the development of reproductive system diseases. In this manuscript, we delineate the constituents of m6A, their biological roles, and advancements in understanding m6A within the maternal-foetal immunological context.In addition, we summarize the mechanism of m6A in gynaecological diseases and provide a new perspective for targeting m6A to delay the progression of reproductive system diseases in clinical practice.
Keywords: RNA modification, epigenetic modification, female reproductive diseases, Reproductive system neoplasms, Treatment
Received: 24 Oct 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Liu, Ge, Lin, Han, Zhao, Cao, Wu and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guizhi Ma, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, Shanghai Municipality, China
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