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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1515768
This article is part of the Research Topic Neuroinflammation: Mechanisms and Therapeutic Interventions View all articles

Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review

Provisionally accepted
Yun Zhao Yun Zhao Ying Tang Ying Tang Qiyao Wang Qiyao Wang *Jia Li Jia Li *
  • Department of Glaucoma, the Second Hospital of Jilin University, Chang Chun, China

The final, formatted version of the article will be published soon.

    With the consistent occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the prevalence of various ocular complications has increased over time. SARS-CoV-2 infection has been shown to have neurotropism and therefore to lead to not only peripheral inflammatory responses but also neuroinflammation. Because the receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), can be found in many intraocular tissues, coronavirus disease 2019 (COVID-19) may also contribute to persistent intraocular neuroinflammation, microcirculation dysfunction and ocular symptoms. Increased awareness of neuroinflammation and future research on interventional strategies for SARS-CoV-2 infection are important for improving long-term outcomes, reducing disease burden, and improving quality of life. Therefore, the aim of this review is to focus on SARS-CoV-2 infection and intraocular neuroinflammation and to discuss current evidence and future perspectives, especially possible connections between conditions and potential treatment strategies.

    Keywords: COVID-19, SARS-CoV-2, Neuroinflammation, Ocular complications, Ocular manifestations

    Received: 23 Oct 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Zhao, Tang, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qiyao Wang, Department of Glaucoma, the Second Hospital of Jilin University, Chang Chun, China
    Jia Li, Department of Glaucoma, the Second Hospital of Jilin University, Chang Chun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.