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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1514422
Immune-Related Diagnostic Indicators and Targeted Therapies for COPD Combined with NASH were Identified and Verified via WGCNA and LASSO
Provisionally accepted- 1 Affiliated Hospital of Nantong University, Nantong, China
- 2 Sixth People's Hospital of Nantong, Nantong, Jiangsu Province, China
The incidence of chronic obstructive pulmonary disease (COPD) and non-alcoholic fatty liver disease (NAFLD) has increased significantly in past decades, posing a significant public health burden. An increasing amount of research points to a connection between COPD and NAFLD. The NAFLD and COPD datasets were obtained from GEO, and S100A9 and MYH2 were identified as key diagnostic genes through various bioinformatics approaches, including differential expression analysis, PPI network construction, LASSO regression, and random forest. qPCR validation was performed, and diagnostic models were developed to enhance diagnostic accuracy. We also revealed some potential biological mechanisms of COPD and NASH as well as potential drugs for the treatment of COPD-associated NASH. Our findings provide potential new diagnostic and therapeutic options for COPD-associated NASH and may reduce the prevalence of COPD-associated NASH.
Keywords: NAFLD, COPD, Inflammation, Immunity, Metabolism, Diagnostic Markers, WGCNA, machine learning
Received: 20 Oct 2024; Accepted: 07 Feb 2025.
Copyright: © 2025 Hong, Xu, Xu, Wu, Liu and Qu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fangrui Xu, Affiliated Hospital of Nantong University, Nantong, China
Haifeng Wu, Sixth People's Hospital of Nantong, Nantong, Jiangsu Province, China
Jinxia Liu, Affiliated Hospital of Nantong University, Nantong, China
Lishuai Qu, Affiliated Hospital of Nantong University, Nantong, China
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