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REVIEW article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1514335
This article is part of the Research Topic The Function and Regulation of T Cell Subsets in Inflammatory Disease View all 8 articles
Regulatory T cells: A promising new therapeutic target in ventricular remodeling after myocardial infarction
Provisionally accepted- 1 Fudan University, Shanghai, Shanghai Municipality, China
- 2 Zhongshan Hospital, Fudan University, Shanghai, Shanghai Municipality, China
Myocardial infarction (MI) is one of the leading causes of death worldwide. It is triggered by thrombosis or vascular occlusion. After MI, damaged cardiomyocytes are replaced by scar tissue, leading to systolic and diastolic dysfunction, followed by adverse remodeling. Regulatory T cells (Tregs), as major immune cells, play a crucial role in post-MI inflammation and immunomodulation. Tregs improve cardiac remodeling after MI through various mechanisms, including inhibiting inflammatory cell infiltration, inducing anti-inflammatory macrophages, suppressing cell apoptosis, regulating fibroblast function, and promoting angiogenesis. The modulation of Tregs number or function may provide novel methods for improving post-MI remodeling. This review describes the immunoregulatory roles of Tregs, their regulatory mechanisms in post-MI ventricular remodeling, and the prospects and challenges for clinical application. However, the exact molecular mechanisms of Tregs in ventricular remodeling remain to be investigated. Although most of the current studies are at the preclinical stage, they hold great potential for further application in the future.
Keywords: regulatory T cells, Myocardial Infarction, Ventricular Remodeling, Immune Regulation, Inflammation
Received: 20 Oct 2024; Accepted: 24 Mar 2025.
Copyright: © 2025 Qin, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haibo Liu, Zhongshan Hospital, Fudan University, Shanghai, 200032, Shanghai Municipality, China
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