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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1513963
This article is part of the Research Topic Molecular Mechanisms and Therapeutic Strategies in Inflammation View all 12 articles
Crosstalk Between H-type Vascular Endothelial Cells and Macrophages: A Potential Regulator of Bone Homeostasis
Provisionally accepted- 1 Gansu Provincial Cancer Hospital, Lanzhou, China
- 2 china, Lanzhou City, Gansu Province, China
The crosstalk between type H endothelial cells (ECs) and macrophages is critical for maintaining angiogenesis and osteogenesis in bone homeostasis. As core components of type H vessels, ECs respond to various pro-angiogenic signals, forming specialized vascular structures characterized by high expression of platelet-endothelial cell adhesion molecule and endomucin, thereby facilitating angiogenesis-osteogenesis coupling during bone formation. Macrophages, as key immune cells in the perivascular region, perform dual functions in regulating local tissue homeostasis and innate immunity. In recent years, the complex crosstalk between type H vessel ECs and macrophages has garnered significant interest in the context of bone-related diseases. However, their interactions in bone homeostasis remain insufficiently understood, with limited clinical data available. This review comprehensively examines the intricate interactions between type H vessel ECs and macrophages with diverse phenotypes, focusing on their roles in angiogenesis and osteogenesis. These insights may offer new perspectives on bone homeostasis and provide a theoretical foundation for developing novel therapeutic strategies.
Keywords: type H vessels, Endothelial Cells, Macrophages, molecular crosstalk, angiogenesisosteogenesis coupling, Bone homeostasis, intervention strategies
Received: 19 Oct 2024; Accepted: 04 Feb 2025.
Copyright: © 2025 Fan, Xie, Liu, Shen, Zuo, Cui and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yaohui Xie, china, Lanzhou City, Gansu Province, China
Desun Liu, china, Lanzhou City, Gansu Province, China
Mengying Shen, china, Lanzhou City, Gansu Province, China
Peng Zuo, china, Lanzhou City, Gansu Province, China
rui Cui, china, Lanzhou City, Gansu Province, China
Linzhong Cao, china, Lanzhou City, Gansu Province, China
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