REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1513037
This article is part of the Research TopicRNA Modifications in Cancer: Unraveling Roles and Therapeutic Potential in Immunity and ImmunotherapyView all 9 articles
Immunomodulatory role of RNA modifications in sex hormone-dependent cancers
Provisionally accepted
- 1Department of Gynecology of Traditional Chinese Medicine, the First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai, China
- 2Department of Reproductive Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, shanghai, China
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Recent studies have identified that RNA epigenetic modifications, including m6A, m1A, m5C, etc, play pivotal roles in tumor progression. These modifications influence mRNA stability, RNA processing, translational efficiency, and decoding precision. However, comprehensive reviews detailing the connection between m6A RNA modifications and hormone-driven cancers in both male and female populations remain scarce(breast cancer, ovarian cancer, and endometrial cancer, prostate cancer). In this article, we explore the cellular and molecular roles of various RNA modifications alongside the key elements of the tumor microenvironment. We examine how these RNA modifications influence the development of hormone-dependent cancers through their impact on immune mechanisms. By enhancing our understanding of the function of RNA modifications within the immune systems of four specific tumors, we offer fresh insights for their potential applications in diagnosis and treatment.
Keywords: RNA modification, sex hormone-dependent cancer, Tumor Microenvironment, Tumor-immunology, epigenetics
Received: 17 Oct 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Jiang, Liang, Sun, Yin, Zhou and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jing Zhou, Department of Gynecology of Traditional Chinese Medicine, the First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai, China
Chaoqin Yu, Department of Gynecology of Traditional Chinese Medicine, the First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai, China
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