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SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1511827
This article is part of the Research Topic Molecular Pathways and Signaling Molecules in Cancer Therapy: Advances and Innovations View all 3 articles
Recent Trends in Research on the Role of Cholesterol in Leukemia: A Bibliometric and Visualization Study
Provisionally accepted
Huijuan Lv
1*
Ke Lu
2
Ximing Wang
3*
Yanfang Zhang
4*
Mengqi Zhuang
1
Jing Li
1*
Keli Su
1*
Wen Gao
5*- 1 Department of Oncology, Fourth People's Hospital of Jinan City, Jinan, China
- 2 Department of Lymphoma, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
- 3 Department of Surgery, The Second People’s Hospital of Jinan, Jinan, Shandong Province, China
- 4 Department of Laboratory, Fourth People's Hospital of Jinan City, Jinan, China
- 5 Department of Cardiology, Fourth People's Hospital of Jinan City, Jinan, China
Background: Cholesterol metabolism significantly impacts leukemia pathophysiology, affecting tumor cell survival, proliferation, and treatment resistance. This study employs bibliometric analysis and visualization techniques to investigate research trends regarding cholesterol in leukemia and identify key hotspots. Methods: A systematic search of the Web of Science Core Collection was performed for literature published from 1980 to 2024 using the keywords "cholesterol" and "leukemia," yielding 1,220 articles. Bibliometric tools like VOSviewer and CiteSpace were utilized for visualizing citation networks and thematic clusters. Results: The analysis comprised 1,220 publications produced by 6,771 researchers across 1,756 institutions in 68 countries, published in 576 journals with 5,903 unique keywords. Publication output demonstrated a significant rise from 1980 to 2024, peaking in 2022. The United States led in total publications (381) and citations (40,462), followed by China (137 articles) and Japan (102). Notably, U.S. publications had lower average citations than those from Germany and Brazil. Key institutions included the University of São Paulo, Medical College of Wisconsin, and National Cancer Institute, with prominent authors such as Maranhao Raul C. and Girotti Albert W. The journal Cancer Research was the most prolific, while Blood had the highest citation frequency. Major research areas encompassed molecular biology, immunology, and medicine, focusing on the cholesterol-leukemia link. Keyword co-occurrence and co-citation analyses reveal increasing interest in topics like STAT3, multidrug resistance, and treatment interactions. These insights suggest crucial areas for further research. Discussion: Our findings emphasize cholesterol's significance in leukemia, indicating its potential as a therapeutic target. Further exploration at the intersection of cholesterol metabolism and leukemia requires multidisciplinary collaboration. Conclusion: This bibliometric study delineates the evolving research landscape on cholesterol's role in leukemia, pinpointing emerging trends and future research directions to inform effective therapeutic strategies.
Keywords: Cholesterol, Leukemia, bibliometric analysis, trend, hot spots, Web of Science
Received: 15 Oct 2024; Accepted: 03 Jan 2025.
Copyright: © 2025 Lv, Lu, Wang, Zhang, Zhuang, Li, Su and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huijuan Lv, Department of Oncology, Fourth People's Hospital of Jinan City, Jinan, China
Ximing Wang, Department of Surgery, The Second People’s Hospital of Jinan, Jinan, Shandong Province, China
Yanfang Zhang, Department of Laboratory, Fourth People's Hospital of Jinan City, Jinan, China
Jing Li, Department of Oncology, Fourth People's Hospital of Jinan City, Jinan, China
Keli Su, Department of Oncology, Fourth People's Hospital of Jinan City, Jinan, China
Wen Gao, Department of Cardiology, Fourth People's Hospital of Jinan City, Jinan, China
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