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CASE REPORT article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1511663
Complete Response of Advanced Esophageal Squamous Cell Carcinoma (ESCC) with First-Line Chemotherapy Combined with Immunotherapy: A Case Report
Provisionally accepted- Hebei General Hospital, Shijiazhuang, China
Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive malignancy, often diagnosed at an advanced stage with poor prognosis. This case report highlights the successful treatment of a patient with advanced ESCC, who presented with bilateral lung and adrenal gland metastases. Despite the aggressive nature of the disease, the patient underwent a regimen of first-line chemotherapy combined with immunotherapy, followed by immune maintenance therapy. Remarkably, the patient achieved complete remission after the completion of treatment, demonstrating the potential efficacy of this combined therapeutic approach in managing advanced ESCC with multiple metastatic sites.
Keywords: Esophageal squamous cell carcinoma (ESCC), Advanced cancer, complete response, chemotherapy, Immunotherapy
Received: 15 Oct 2024; Accepted: 17 Feb 2025.
Copyright: © 2025 Wei, Han, Shi, Li, Zhang, Zhang, Cheng and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaolu Yan, Hebei General Hospital, Shijiazhuang, China
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