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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1511616
This article is part of the Research Topic Regulators of the Immune-Tumor Microenvironment: A New Frontier for Cancer Immunotherapy View all 18 articles
Advances in the Role of NK Cells in MDS Immune Dysfunction and Antitumor Research
Provisionally accepted- 1 Lanzhou University Second Hospital, Lanzhou, China
- 2 Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
MDS is a heterogeneous group of myeloid neoplasms originating from hematopoietic stem cells, with a high risk of transformation into acute myeloid leukemia (AML). Natural Killer (NK) cells, crucial for their role in immune surveillance and efficient tumor cell lysis, experience functional impairments due to the complex microenvironment and cytokine dynamics in MDS. This article focuses on the mechanisms of NK cell dysfunction in MDS and the latest strategies to enhance NK cell activity to restore their anti-MDS efficacy, highlighting their key role and potential in MDS therapy.
Keywords: NK cell, Myelodysplastic Syndromes, Tumor Microenvironment, Immunotherapy, review
Received: 15 Oct 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 wang, Feng, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
zuxi Feng, Lanzhou University Second Hospital, Lanzhou, China
lijuan Li, Department of Hematology, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu Province, China
Liansheng Zhang, Department of Hematology, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu Province, China
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