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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1509719
This article is part of the Research Topic Community Series in : The Role of Vitamin D as an Immunomodulator - Volume II View all 7 articles
The relationship between vitamin D levels, D-dimer and platelet parameter levels in patients with gestational hypertension
Provisionally accepted
Pingping Wang 1*
Jin Yao 2 Yaqiong Li 1 Zhanjun Zhang 1 Ruiling Zhang, 3
Shouting Lu 3 Meixia Sun 3
Xiaorong Huang 3- 1 Luoyang Maternal and Child Health Hospital, Luoyang City, China
- 2 The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang City, China
- 3 Luoyang Institute of Science and Technology, Luoyang, China
Hypertension during pregnancy is a common pregnancy complication that has an important impact on maternal and fetal health. In recent years, studies have shown that vitamin D, D dimers and platelet parameters may play a key role in the occurrence and development of gestational hypertension. Objective: This study aimed to explore the relationship between vitamin D levels, D dimers and platelet parameters in patients with gestational hypertension. Material and methods:This study retrospectively analyzed the clinical data of 90 patients with gestational hypertension and 90 normal pregnant women who were treated in our hospital from September 2022 to September 2023. We compared the blood routine indicators between the two groups, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), etc., as well as D dimer and vitamin D (Vit D) levels.The results showed that the vitamin D level and PLT in the gestational hypertension group were significantly lower than those in the normal pregnant group, while MPV and PDW were significantly increased. In addition, vitamin D levels were significantly correlated with D dimer, MPV and PDW. Further statistical analysis showed that vitamin D, D dimer and platelet parameters were important predictors of gestational hypertension.This study found that patients with gestational hypertension have vitamin D deficiency and abnormal platelet function. Vitamin D may affect the development of the disease by regulating platelet activity and coagulation status, which may be closely related to its pathological mechanism. This suggests that improving vitamin D status may have potential value in the management of gestational hypertension.
Keywords: Gestational hypertension, Vitamin D, D dimer, Platelet parameters, Correlation
Received: 11 Oct 2024; Accepted: 27 Feb 2025.
Copyright: © 2025 Wang, Yao, Li, Zhang, Zhang,, Lu, Sun and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Pingping Wang, Luoyang Maternal and Child Health Hospital, Luoyang City, China
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