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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1508730
This article is part of the Research Topic Metabolism in the Tumour Microenvironment: Implications for Pathogenesis and Therapeutics View all articles
Targeting Amino Acid Metabolism to Inhibit Gastric Cancer Progression and Promote Anti-tumor Immunity: A Review
Provisionally accepted
Yuchun Jiang 
Qing Tao * Xuehan Qiao *
Yang Yufei Chen Peng *
Miao Han Kebin Dong * Wei Zhang *
Min Xu 
Deqiang Wang * Wen Zhu *
Xiaoqin Li *- Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
The incidence of gastric cancer remains high and poses a serious threat to human health. Recent comprehensive investigations into amino acid metabolism and immune system components within the tumor microenvironment have elucidated the functional interactions between tumor cells, immune cells, and amino acid metabolism. This study reviews the characteristics of amino acid metabolism in gastric cancer, with a particular focus on the metabolism of methionine, cysteine, glutamic acid, serine, taurine, and other amino acids. It discusses the relationship between these metabolic processes, tumor development, and the body's anti-tumor immunity, and analyzes the importance of targeting amino acid metabolism in gastric cancer for chemotherapy and immunotherapy.
Keywords: amino acid metabolism1, immunotherapy2, chemotherapy resistance3, Tumor microenvironment4, methylation5. (Min
Received: 09 Oct 2024; Accepted: 24 Jan 2025.
Copyright: © 2025 Jiang, Tao, Qiao, Yufei, Peng, Han, Dong, Zhang, Xu, Wang, Zhu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qing Tao, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
Xuehan Qiao, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
Chen Peng, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
Kebin Dong, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
Wei Zhang, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
Deqiang Wang, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
Wen Zhu, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
Xiaoqin Li, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
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