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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1507080
Effects of maternal-offspring supplementation of probiotics and synbiotics on the immunity of offspring Bama mini-pigs
Provisionally accepted- 1 Institute of Subtropical Agriculture, Chinese Academy of Sciences (CAS), Changsha, China
- 2 Hunan Agricultural University, Changsha, Hunan, China
Maternal nutrition is one of the main factors regulating the growth and immunity of piglets. This study aimed to investigate the effects of maternal and maternal-offspring supplementation of antibiotics, probiotics, and synbiotics on the immunity of offspring (21, 65, and 125 day-old) in Bama mini-pigs. The results showed that adding antibiotics to maternal diets increased the plasma IFN-γ level of offspring piglets at 21 day-old. Compared with maternal supplementation, maternal-offspring supplementation of antibiotics decreased the IL-10 level in the spleen, probiotics decreased IL-2, IL-10, and TNF-α levels in the ileum, and synbiotics decreased IL-10 and IFN-γ levels in the ileum of offspring piglets. Moreover, maternal-offspring antibiotics supplementation increased the IL-1β level in the ileum, while probiotics supplementation increased the IL-1β level in the spleen of offspring piglets. Maternal antibiotics supplementation increased the TNF-α level in the ileum at 95 day-old compared with maternal probiotics and synbiotics supplementation. Maternal-offspring antibiotics supplementation increased the IL-1β level in the ileum compared with the probiotics supplementation, while synbiotics supplementation increased the IL-6 level in the ileum than the probiotics and antibiotics supplementation at 95 day-old. Moreover, maternal-offspring probiotics supplementation increased the IL-1β level in the spleen of offspring pigs, which was higher than the maternal probiotics supplementation. These findings suggest that the immune function of the offspring piglets varied depending on the specific approach used for probiotics and synbiotics supplementation.
Keywords: Bama mini-pigs, Immunity, Maternal-offspring, Probiotics, Synbiotics
Received: 07 Oct 2024; Accepted: 27 Jan 2025.
Copyright: © 2025 Kong, Ding, Ye, Azad, Zhu, Yating and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiangfeng Kong, Institute of Subtropical Agriculture, Chinese Academy of Sciences (CAS), Changsha, China
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