Healthy and premature aging of monocytes and macrophages

Basu, Syamantak; Ulbricht, Ying; Rossol, Manuela

doi:10.3389/fimmu.2025.1506165

REVIEW article

Front. Immunol.

Sec. Cytokines and Soluble Mediators in Immunity

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1506165

This article is part of the Research Topic Immunity in Aging and Age-related Diseases and Dysfunctions View all 6 articles

Healthy and premature aging of monocytes and macrophages

Provisionally accepted

Syamantak Basu

Ying Ulbricht

Manuela Rossol ^*

Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany

The final, formatted version of the article will be published soon.

Aging is associated with immunosenescence, a decline in immune functions, but also with inflammaging, a chronic, low-grade inflammation, contributing to immunosenescence. Monocytes and macrophages belong to the innate immune system and aging has a profound impact on these cells, leading to functional changes and most importantly, to the secretion of pro-inflammatory cytokines and thereby contributing to inflammaging.Rheumatoid arthritis (RA) is an autoimmune disease and age is an important risk factor for developing RA. RA is associated with the early development of age-related comorbidities like cardiovascular manifestations and osteoporosis. The immune system of RA patients shows signs of premature aging like age-inappropriate increased production of myeloid cells, accelerated telomeric erosion, and the uncontrolled production of pro-inflammatory cytokines.In this review we discuss the influence of aging on monocytes and macrophages during healthy aging and premature aging in rheumatoid arthritis. related decline in immune functions.87 hat gelöscht: and a 88 hat gelöscht: . 89 hat gelöscht: , 90 hat gelöscht: and show a premature aging of the 91 immune system (7). … 92 hat gelöscht: T cells are the most affected and the most 93 studied, immune cells in RA (8,9). Naive T cells in RA hat gelöscht: ¶ 130 hat gelöscht: ¶ 131 hat gelöscht: people 132 hat gelöscht: people 133 hat gelöscht: people 134 hat gelöscht: , 135 hat gelöscht: , 136 hat gelöscht: and also the 137 hat gelöscht: .

Keywords: Monocytes, Macrophages, Aging, immunosenescence, Rheumatoid arthritis, Inflammaging

Received: 04 Oct 2024; Accepted: 28 Feb 2025.

Copyright: © 2025 Basu, Ulbricht and Rossol. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Manuela Rossol, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany

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