Skip to main content

REVIEW article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1499014
This article is part of the Research Topic Cellular and Molecular Regulators in Non-neoplastic Immune-mediated Diseases View all 4 articles

The Function of T Cells in Immune Thrombocytopenia

Provisionally accepted
Siyuan Bu Siyuan Bu 1Min Liu Min Liu 2Lu Yang Lu Yang 3Pamela Lee Pamela Lee 4Heather Miller Heather Miller 5Chan-Sik Park Chan-Sik Park 6Maria Byazrova Maria Byazrova 7Alexander Filatov Alexander Filatov 7Kamel Benlagha Kamel Benlagha 8Timo Gaber Timo Gaber 9Frank Buttgereit Frank Buttgereit 9Quan Gong Quan Gong 10*Zhimin Zhai Zhimin Zhai 11*Chaohong Liu Chaohong Liu 12*
  • 1 Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
  • 2 Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany
  • 3 Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  • 4 Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Region, China
  • 5 Cytek Biosciences, Fremont, California, United States
  • 6 Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea
  • 7 National Research Center Institute of Immunology, Federal Medical & Biological Agency of Russia, Moscow, Moscow Oblast, Russia
  • 8 Institut de Recherche Saint Louis, Université de Paris, Paris, France
  • 9 Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Baden-Württemberg, Germany
  • 10 Department of Immunology, School of Medicine, Yangtze University, Jingzhou, China
  • 11 Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, Anhui Province, China
  • 12 Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Immune thrombocytopenia (ITP) is an autoimmune disease, characterized by increased bleeding due to a reduced platelet count. The pathogenesis of ITP is very complex and involves autoantibody production and T-cell-mediated immune abnormalities. An imbalance of effector and regulatory CD4 + T cells and the breach of tolerance primarily cause ITP, leading to the dysfunctional development of autoreactive Th cells (including Th1, Th2, and Th17 cells) and Tregs. The loss of auto-platelet antigen tolerance in ITP results in autoantibody-and cytotoxic T-cellmediated platelet clearance. T-cell-related genetic risk factors significantly influence the development and progression of this disease. New therapies targeting T cells have emerged as potentially effective cures for this disease. This review summarizes the role of T cells in ITP.

    Keywords: immune thrombocytopenia, Cd4 + t cell, CD8 + T cell, genetic factors, T cell

    Received: 20 Sep 2024; Accepted: 20 Jan 2025.

    Copyright: © 2025 Bu, Liu, Yang, Lee, Miller, Park, Byazrova, Filatov, Benlagha, Gaber, Buttgereit, Gong, Zhai and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Quan Gong, Department of Immunology, School of Medicine, Yangtze University, Jingzhou, 434023, China
    Zhimin Zhai, Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, 230601, Anhui Province, China
    Chaohong Liu, Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.