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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1497174
This article is part of the Research Topic Pattern Recognition Receptors: Balancing Inflammation and Immune Homeostasis View all articles

Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing Authors

Provisionally accepted
Tzu Hsuan Chang Tzu Hsuan Chang 1Yamel Cardona Yamel Cardona 1Margareta J. Hellmann Margareta J. Hellmann 2Timmy Richardo Timmy Richardo 1,3Carsten Leo Greve Carsten Leo Greve 3DIDIER LEROY DIDIER LEROY 4Thierry Roger Thierry Roger 4Francesca Bork Francesca Bork 3Stefanie Bugl Stefanie Bugl 3Johanna Jakob Johanna Jakob 3Johannes Sonnberger Johannes Sonnberger 5Lydia Kasper Lydia Kasper 5Bernhard Hube Bernhard Hube 5Stefan Pusch Stefan Pusch 6Neil Andrew Robert Gow Neil Andrew Robert Gow 7Morten Sørlie Morten Sørlie 8Anne Tøndervik Anne Tøndervik 9Bruno Moerschbacher Bruno Moerschbacher 2Alexander Norman Rainer Weber Alexander Norman Rainer Weber 1*
  • 1 University of Tübingen, Tübingen, Germany
  • 2 Institute for Biology and Biotechnology of Plants, University of Münster, Schlossplatz 8, 48143 Münster, Germany, Münster, Germany
  • 3 Institute of Immunology, Department of Innate Immunity, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany, Tübingen, Germany
  • 4 Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Lausanne, Switzerland
  • 5 Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany., Jena, Germany
  • 6 Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg and Clinical Cooperation Unit (CCU) Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 7 MRC Centre for Medical Mycology, College of Life and Environmental Sciences, University of Exeter, Exeter, England, United Kingdom
  • 8 Department of Chemistry, Biotechnology, and Food Science, Norwegian University of Life Sciences PB 5003 Chr. M. Falsensvei 1, N-1432 Ås, Norway, Aas, Norway
  • 9 Department of Biotechnology and Nanomedicine, SINTEF Industry, Richard Birkelands vei 3B, N-7034 Trondheim, Norway, Trondheim, Norway

The final, formatted version of the article will be published soon.

    carbohydrate binding module (CBM), chitotriosidase (CHIT1), concanavalin A (ConA), enzyme-linked immunosorbent assay (ELISA), glycoside hydrolases 18 (GH18), human embryonic kidney (HEK), house dust mite (HDM), interferon (IFN), immortalized macrophages (iMacs), interleukin (IL), knockout (KO), lipopolysaccharide (LPS), microbe-associated molecular pattern (MAMP), myeloid differentiation factor 2 (MD-2), N-acetylglucosamine (GlcNAc), nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB), pattern recognition receptors (PRRs), secreted aspartyl proteases (Sap), Toll-like receptor (TLR), tumor necrosis factor (TNF).

    Keywords: Chitin, chitotriosidase, N-acetyl-glucosamine, Toll-like receptor (TLR), Inflammation, myeloid cell, innate immunity, Candida albicans

    Received: 16 Sep 2024; Accepted: 04 Feb 2025.

    Copyright: © 2025 Chang, Cardona, Hellmann, Richardo, Greve, LEROY, Roger, Bork, Bugl, Jakob, Sonnberger, Kasper, Hube, Pusch, Gow, Sørlie, Tøndervik, Moerschbacher and Weber. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Alexander Norman Rainer Weber, University of Tübingen, Tübingen, Germany

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