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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1493950
This article is part of the Research TopicCommunity Series in Targeting Signalling Pathways in Inflammatory Diseases - Volume IIView all 13 articles
Airway epithelial cell-specific deletion of EGFR modulates mucoinflammatory features of cystic fibrosis-like lung disease in mice
Provisionally accepted- 1North Carolina State University, Raleigh, North Carolina, United States
- 2National Institute of Environmental Health Sciences (NIH), Durham, North Carolina, United States
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Author Contributions: IC, SP, and YS conceived and designed the study. IC and YS maintained the animal colony, conducted animal necropsies, and performed BALF cellularity assays, cytokine, microbiological, and histological experiments. IC, KP, and YS performed survivability analyses, body weight experiments, and immunohistochemical staining. IC, AS, and RK IC and RK performed gene expression assays. IC, SP, and YS performed histopathological analyses. IC, SP, and YS wrote and reviewed the manuscript for intellectual contents. All authors contributed to the article and approved the submitted version.
Keywords: EGFR, Cystic Fibrosis, Scnn1b-Tg+, Airway epithelium, mucus obstruction
Received: 10 Sep 2024; Accepted: 09 Apr 2025.
Copyright: © 2025 Choudhary, Paudel, Kumar, Patial and Saini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yogesh Saini, North Carolina State University, Raleigh, 27695, North Carolina, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.