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REVIEW article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1487814

Neutrophils, NETs and Multiple Sclerosis：A Mini Review

Provisionally accepted
Moyuan Quan Moyuan Quan 1Huining Zhang Huining Zhang 1Xiaohong Deng Xiaohong Deng 2Huijia Liu Huijia Liu 3Yanqiu Xu Yanqiu Xu 4Xiujuan Song Xiujuan Song 1*
  • 1 Second Hospital of Hebei Medical University, Shijiazhuang, China
  • 2 Beijing Zhongguancun Hospital, Beijing, China
  • 3 the military special care hospital of shijiazhuang, shijiazhuang, China
  • 4 Third Hospital of Shijiazhuang, Shijiazhuang, Hebei Province, China

The final, formatted version of the article will be published soon.

    Multiple sclerosis (MS), a chronic inflammatory and degenerative autoimmune disease characterized by the activation of various inflammatory cells, leads to demyelination and neuronal injury. Neutrophils, often underestimated in MS, are gaining increased attention for their significant functions in MS patients and the experimental autoimmune encephalomyelitis (EAE) animal model. Neutrophils play multiple roles in mediating the pathogenesis of autoimmune diseases, and numerous studies suggest that neutrophils might have a crucial role through neutrophil extracellular trap (NET) formation. Studies on NETs in MS are still in their infancy.In this review, we discuss the clinical perspective on the linkage between neutrophils and MS or EAE, as well as the role of NETs in the pathogenesis of MS/EAE. Further, we analyze the potential mechanisms by which NETs contribute to MS, the protective effects of NETs in MS, and their value as targets for disease intervention. NET formation and/or clearance as a therapeutic approach for MS still requires research in greater depth.

    Keywords: Multiple Sclerosis, Experimental autoimmune encephalomyelitis, Neutrophils, neutrophil extracellular traps, Therapeutic target

    Received: 28 Aug 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Quan, Zhang, Deng, Liu, Xu and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiujuan Song, Second Hospital of Hebei Medical University, Shijiazhuang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.