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SYSTEMATIC REVIEW article

Front. Immunol.
Sec. Viral Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1478187
This article is part of the Research Topic Neurocognitive Dysfunction in People Living with HIV and the Underlying Brain Mechanisms View all 6 articles

Development of research on HIV-associated neurocognitive disorder and emerging trends: A visualization analysis via CiteSpace

Provisionally accepted
Tingting Zhou Tingting Zhou Xuannan Chen Xuannan Chen Yu Lai Yu Lai *
  • Chengdu University of Traditional Chinese Medicine, Chengdu, China

The final, formatted version of the article will be published soon.

    Background: In the combination antiretroviral therapy era, HIV-associated neurocognitive disorder (HAND) is still widespread among HIV-infected individuals. However, there is no effective treatment for HAND, and the exact pathogenic mechanism of HAND remains unknown. This paper aims to provide a reference for further exploration in the field of HAND research.We used CiteSpace software to collect 3057 articles related to HAND in the Web of Science Core Collection for comprehensive analysis. Betweenness centrality, count, and burst values were used as indicators in the visualization analysis, aiming to predict future new directions and cutting-edge trends.The last decade has been the peak period of HAND research, with the most prominent contributions by authors, countries, and institutions being Grant, Igor (135), the USA (2211), and the University of California System (758), respectively. The most frequently cited article is "HIVassociated neurocognitive disorders persist in the area of potent antiretroviral therapy: CHARTER Study." The hotspots in this field are "neurocognitive impairment," "central nervous system," "cerebrospinal fluid," "HIV-1 tat," "SIV," "inflammation," "infection," and "pathogenesis." The current research direction of HAND is focused on exploring the pathogenic mechanism underlying HIV-associated neurocognitive impairment and potential therapeutic targets.This study provides a bibliometric visualization of HAND-related literature to gain insight into the development and frontiers of this research field. The study also provides scholars

    Keywords: HIVAIDS1, HIV-associated neurocognitive disorder2, neurocognitive impairment3 CiteSpace4, Bibliometric analysis5, visualized analysis6, emerging trends7

    Received: 09 Aug 2024; Accepted: 20 Jan 2025.

    Copyright: © 2025 Zhou, Chen and Lai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yu Lai, Chengdu University of Traditional Chinese Medicine, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.