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CASE REPORT article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1460034

Case report: Plasma exchange as a therapy for Miller-Fisher syndrome

Provisionally accepted
Dongmei Guan Dongmei Guan 1Yuanzhuang SHAN Yuanzhuang SHAN 1*Hailin ZHANG Hailin ZHANG 2*
  • 1 Shandong University of Traditional Chinese Medicine, Jinan, China
  • 2 Jining First People's Hospital, Jining, Shandong, China

The final, formatted version of the article will be published soon.

    This is a report of an anti-GQ1b antibody-negative case of Miller-Fisher syndrome, presenting with diplopia and gait disturbance 3 days after catching a cold, accompanied by dizziness and headache, pain in the eyeballs and orbits, superficial sensory loss, ptosis, eye movements fixed in the middle of eyes, and limb weakness. Physical examination suggested that the patient had eye movements fixed in the middle of the eyes, limb muscle strength was reduced, and the bilateral fingerto-nose and heel-knee-shin tests were clumsy and dysmetric. Assistant examinations showed albumin-cytologic dissociation in cerebrospinal fluid, incomplete bilateral facial nerve lesions, and negative anti-GQ1b antibody. After being treated with plasma exchange, the patient experienced slight improvement in eye adduction when she was discharged from the hospital and her diplopia and limb weakness were significantly improved. She could walk independently without dizziness or headache and the pain in her eyeballs and orbits was completely relieved.

    Keywords: Miller-Fisher syndrome, Ophthalmoplegia, Guillain-Barré syndrome, case report, Plasma Exchange

    Received: 08 Jul 2024; Accepted: 31 Jan 2025.

    Copyright: © 2025 Guan, SHAN and ZHANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuanzhuang SHAN, Shandong University of Traditional Chinese Medicine, Jinan, China
    Hailin ZHANG, Jining First People's Hospital, Jining, Shandong, China

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