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CASE REPORT article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1457907
This article is part of the Research Topic Understanding and Treating Rare Nasal and Paranasal Sinus Cancers View all 6 articles

Sinonasal small cell carcinoma combined concurrently with small cell lung carcinoma: case report and literature review

Provisionally accepted
Rencui Quan Rencui Quan Ling Han Ling Han Shihai Wu Shihai Wu *Xianming Li Xianming Li *
  • Shenzhen People's Hospital, Jinan University, Shenzhen, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Sinonasal small cell neuroendocrine carcinoma (SCNEC) is an uncommon malignant epithelial neuroendocrine tumor in the sinonasal cavity that often presents in isolation and rarely occurs in synchronous fashion with small cell lung carcinoma (SCLC). Here, we present a case of a 65-year-old man diagnosed with SCNEC concurrently combined with SCLC. He received first-line platinum-doublet chemotherapy combined with durvalumab, followed by radiotherapy to thoracic as well as head and neck regions. The follow-up computed tomography and magnetic resonance imaging showed a complete response according to Response Evaluation Criteria in Solid Tumors criteria until 9 June 2024. This case highlights the need for accurate diagnostic characterization of primary lesions and the need to formalize treatment paradigms using chemotherapy, radiation therapy, immunotherapy with immune checkpoint inhibitors, and targeted prophylactic cranial irradiation.

    Keywords: Sinonasal small cell neuroendocrine carcinoma, Small cell lung carcinoma (SCLC), immune checkpoint inhibitors, PD-L1, Maintenance treatment

    Received: 01 Jul 2024; Accepted: 08 Jan 2025.

    Copyright: © 2025 Quan, Han, Wu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shihai Wu, Shenzhen People's Hospital, Jinan University, Shenzhen, 518000, Guangdong Province, China
    Xianming Li, Shenzhen People's Hospital, Jinan University, Shenzhen, 518000, Guangdong Province, China

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