The final, formatted version of the article will be published soon.
REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1425901
This article is part of the Research Topic Community Series in Targeting Signalling Pathways in Inflammatory Diseases - Volume II View all 11 articles
Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis
Provisionally accepted
Muhammad Zahoor Khan 1*
Liangliang Li 1*
Yandong Zhan 1 Huang Binjiang 1* Xiaotong Liu 1* Xiyan Kou 1*
Adnan Khan 2
Abdul Qadeer 1
Qudrat Ullah 3
Khalid Alzahrani 4
Tongtong Wang 1 Changfa Wang 1*
Muhammad Zahoor 5*- 1 Liaocheng University, Shangdong, China
- 2 Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 511464, China, Shenzhen, China
- 3 Department of Theriogenology, Faculty of Veterinary and Animal Sciences, Cholistan University of Veteri-nary and Animal Sciences, Bahawalpur, Punjab, Pakistan, Bahawalpur, Pakistan
- 4 Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia, Taif, Saudi Arabia
- 5 Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien, 90372 Oslo, Norway, oslo, Norway
Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide. Elevated reactive oxygen species (ROS) followed by oxidative stress, apoptosis, inflammatory changes and suppressed immunity are considered the key biomarkers observed during mastitis. The Nrf2/KEAP1 signaling pathway plays a critical role in regulating antioxidant responses and cellular defense mechanisms. When activated by bioactive compound treatment, Nrf2 translocates to the nucleus and induces the expression of its target genes to exert antioxidant responses. This reduces pathogen-induced oxidative stress and inflammation by inhibiting NF-kB signaling in the mammary glands, one of the prominent pro-inflammatory signaling pathway. Here, we summarize recent studies to highlight the therapeutic potential of Nrf2/KEAP1 pathway in the prevention and treatment of mastitis. Collectively this review article aims to explore the potential of bioactive compounds in mitigating mastitis by targeting the Nrf2/KEAP1 signaling pathway.
Keywords: Mastitis, Inflammation, Immunity, Oxidative Stress, Antioxidants, bioactive compounds, Nrf2/Keap1 signaling pathway
Received: 30 Apr 2024; Accepted: 20 Jan 2025.
Copyright: © 2025 Khan, Li, Zhan, Binjiang, Liu, Kou, Khan, Qadeer, Ullah, Alzahrani, Wang, Wang and Zahoor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Muhammad Zahoor Khan, Liaocheng University, Shangdong, China
Liangliang Li, Liaocheng University, Shangdong, China
Huang Binjiang, Liaocheng University, Shangdong, China
Xiaotong Liu, Liaocheng University, Shangdong, China
Xiyan Kou, Liaocheng University, Shangdong, China
Changfa Wang, Liaocheng University, Shangdong, China
Muhammad Zahoor, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien, 90372 Oslo, Norway, oslo, Norway
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.