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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1420132
This article is part of the Research Topic Nutritional Factors in the Development and Prognosis of Inflammatory Bowel Disease (IBD) View all 6 articles
The Relationship Between Amino Acids and Gastroesophageal Reflux Disease: Evidence from a Mendelian Randomization Analysis Combined with a Meta-Analysis
Provisionally accepted- 1 Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, China
- 2 Capital Institute of Physical Education and Sports, Beijing, Beijing, China
Gastroesophageal Reflux Disease (GERD), a prevalent gastrointestinal disorder globally, exhibits variable prevalence across regions, with higher frequencies observed in Western nations and lower in Asian countries. Key contributing factors encompass unhealthy eating patterns, tobacco use, consumption of alcohol, excess weight, and obesity, along with health conditions such as gestation and diabetes. Common manifestations include heartburn and a burning discomfort behind the breastbone, which, without appropriate management, can progress to more severe issues like esophagitis and Barrett's esophagus. Approaches to management and prevention primarily involve modifications in lifestyle, pharmacotherapy, and surgical interventions when deemed necessary.Utilizing Omics Mendelian Randomization (OMR) to investigate the causative links between genetic variants and diseases provides insights into the biological underpinnings of gastroesophageal reflux diseasec. It aids in pinpointing novel targets for therapy. The influence of amino acids in nutritional management. This insight can aid in developing healthier dietary plans, thereby benefiting patients.
Keywords: amino acids1, Gastroesophageal reflux disease2, the omics mendelian randomization3. meta analysis4, authenticate reverse5, multiple corrections6
Received: 19 Apr 2024; Accepted: 06 Feb 2025.
Copyright: © 2025 Shen, Guo and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yongqing Guo, Capital Institute of Physical Education and Sports, Beijing, 100088, Beijing, China
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