Skip to main content

REVIEW article

Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1345855

Advances in Allogeneic Hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children

Provisionally accepted
Guangqiang Meng Guangqiang Meng *Saran Feng Saran Feng Yan Wang Yan Wang
  • Shandong Provincial Qianfoshan Hospital, Jinan, China

The final, formatted version of the article will be published soon.

    Langerhans cell histiocytosis (LCH) is a disease caused by clonal expansion of CD1a+/CD207+ cells and is characterised by organ involvement and dysfunction. Treatment of LCH in children is risk-adapted, and multisystem LCH requires systemic therapy. Although systemic treatments such as chemotherapy and BRAF/MEK inhibitors have improved the cure rate of LCH, disease reactivation rates remain 30%, and eventually some patients progress to relapse-refractory LCH.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a promising salvage treatment strategy for children with relapse-refractory LCH. However, many questions such as the efficacy and indications of allo-HSCT, as well as suitable conditioning regimen are still undetermined for children with LCH. This review aimed to provide an update on advances in allo-HSCT for LCH in children, including indications, stem cell sources, conditioning regimens, chimerism, transplant-related complications, outcomes, and treatment of relapse.

    Keywords: langerhans cell histiocytosis, Allogeneic haematopoietic stem cell transplantation, Myeloablative conditioning, reduced intensity conditioning, Chimerism

    Received: 28 Nov 2023; Accepted: 13 Jan 2025.

    Copyright: © 2025 Meng, Feng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guangqiang Meng, Shandong Provincial Qianfoshan Hospital, Jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.