This article is a correction to:
Heterogeneous phenotype of a Chinese Familial WHIM Syndrome with CXCR4 V340fs Gain-of-function Mutation
Yu Huang1,2,3†
Lu Li1,2†Ran Chen1,2
Lang Yu1,2Shunkai Zhao4Yanjun Jia1,2
Ying Dou1,2,3Zhiyong Zhang1,5
Yunfei An1,5
Xuemei Tang1,5
Xiaodong Zhao1,5*
Lina Zhou1*- 1National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, China
- 2Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Children’s Hospital of Chongqing Medical University, Chongqing, China
- 3Department of Hematology Oncology, Children’s Hospital of Chongqing Medical University, Chongqing, China
- 4Department of Biology, School of Arts and Sciences, Tufts University, Medford, MA, United States
- 5Department of Rheumatism and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China
A Corrigendum on
Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4V340fs gain-of-function mutation
By Huang Y, Li L, Chen R, Yu L, Zhao S, Jia Y, Dou Y, Zhang Z, An Y, Tang X, Zhao X and Zhou L (2024) Front. Immunol. 15:1460990. doi: 10.3389/fimmu.2024.1460990
In the published article, there was an error. A typo was made.
A correction has been made to Abstract, Results, Paragraph 1. This sentence previously stated:
“We provide and in-depth analysis of their clinical, genetic, immunological and treatment characteristic, noting that these patients exhibited an atypical clinical phenotype when compared to reported CXCR4R334X patients.”
The corrected sentence appears below:
“We provide an in-depth analysis of their clinical, genetic, immunological and treatment characteristic, noting that these patients exhibited an atypical clinical phenotype when compared to reported CXCR4R334X patients.”
1. In the published article, there was an error. A typo was made.
A correction has been made to Introduction, Paragraph 2. This sentence previously stated:
“Thirty-seven distinct CXCR4 variants have been identified, whice including eight nonsense variants, twenty-seven frameshift variants, and two missense variants.”
The corrected sentence appears below:
Thirty-seven distinct CXCR4 variants have been identified, which including eight nonsense variants, twenty-seven frameshift variants, and two missense variants.”
2. In the published article, there was an error. Omission of important information.
A correction has been made to Results, Clinical manifestations of the family with WHIM syndrome, Paragraph 3. This sentence previously stated:
“At the age of, P2 was hospitalized due to edema, and subsequent tests showed proteinuria, hyperlipidemia, and hypoproteinemia, leading to a diagnosis of nephrotic syndrome.”
The corrected sentence appears below:
“At the age of 4, P2 was hospitalized due to edema, and subsequent tests showed proteinuria, hyperlipidemia, and hypoproteinemia, leading to a diagnosis of nephrotic syndrome.”
3. In the published article, there was an error. A typo was made.
A correction has been made to Results, Decreased surface CXCR4 expression on CD8+T cells and B cells from patients, Paragraph 1. This sentence previously stated:
“Interestingly, P1-P4 exhibited relatively higher levels of CXCR4 lexpression, particularly in pediatric patients P1 and P2 (Supplementary Figure SA).”
The corrected sentence appears below:
“Interestingly, P1-P4 exhibited relatively higher levels of CXCR4 expression, particularly in pediatric patients P1 and P2 (Supplementary Figure SA).”
4. In the published article, there was an error. A typo was made.
A correction has been made to Discussion, Paragraph 4. This sentence previously stated:
“n our cohort, all four patients exhibited varying degrees of impaired CXCR4 internalization; pediatric patients showed reduced internalization, while adult patients demonstrated no internalization.”
The corrected sentence appears below:
“In our cohort, all four patients exhibited varying degrees of impaired CXCR4 internalization; pediatric patients showed reduced internalization, while adult patients demonstrated no internalization.”
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: CXCR4 variant, gain-of-function, inborn error of immunity, WHIM syndrome, heterogeneous phenotype
Citation: Huang Y, Li L, Chen R, Yu L, Zhao S, Jia Y, Dou Y, Zhang Z, An Y, Tang X, Zhao X and Zhou L (2025) Corrigendum: Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4V340fs gain-of-function mutation. Front. Immunol. 15:1544964. doi: 10.3389/fimmu.2024.1544964
Received: 13 December 2024; Accepted: 16 December 2024;
Published: 14 January 2025.
Approved by:
Frontiers Editorial Office, Frontiers Media SA, SwitzerlandCopyright © 2025 Huang, Li, Chen, Yu, Zhao, Jia, Dou, Zhang, An, Tang, Zhao and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lina Zhou, cmFjaGVsemhvdTg4QHFxLmNvbQ==; Xiaodong Zhao, emhhb3hkNTMwQGFsaXl1bi5jb20=
†These authors have contributed equally to this work and share first authorship