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MINI REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1539696
This article is part of the Research Topic Harnessing Molecular Insights for Enhanced Drug Sensitivity and Immunotherapy in Cancer View all 12 articles

New Insights into the Mechanisms of the Immune Microenvironment and Immunotherapy in Osteosarcoma

Provisionally accepted
Cong Luo Cong Luo 1Xingxing Min Xingxing Min 1Danying Zhang Danying Zhang 2*
  • 1 Department of Orthopedic Trauma, Zhuji People's Hospital of Zhejiang Province, Zhejiang, China, Zhejiang, China
  • 2 Department of Emergency and Critical Care, Shanghai Changzheng Hospital, Shanghai, China, Sahnghai, China

The final, formatted version of the article will be published soon.

    Osteosarcoma, a malignant bone tumor primarily affecting adolescents, is highly invasive with a poor prognosis. While surgery and chemotherapy have improved survival for localized cases, pulmonary metastasis significantly reduces survival to approximately 20%, highlighting the need for novel treatments. Immunotherapy, which leverages the immune system to target osteosarcoma cells, shows promise. This review summarizes the biological characteristics of osteosarcoma, mechanisms of pulmonary metastasis, and the tumor immune microenvironment (TME). It involves recent immunotherapy advances, including monoclonal antibodies, tumor vaccines, immune cell therapies, checkpoint inhibitors, and oncolytic viruses, and discusses combining these with standard treatments.

    Keywords: Osteosarcoma, immune microenvironment, Immunotherapy, Immune Evasion, combination therapy

    Received: 04 Dec 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Luo, Min and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Danying Zhang, Department of Emergency and Critical Care, Shanghai Changzheng Hospital, Shanghai, China, Sahnghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.