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EDITORIAL article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1527428
This article is part of the Research Topic Immune Cell Exhaustion: New Challenges and Opportunities in Cancer Therapy View all 5 articles

Editorial: Immune Cell Exhaustion: New Challenges and Opportunities in Cancer Therapy

Provisionally accepted
Hao Chi Hao Chi 1Lai Jiang Lai Jiang 1Xuancheng Zhou Xuancheng Zhou 1Lexin Wang Lexin Wang 2Guanhu Yang Guanhu Yang 3Honghao Luo Honghao Luo 4*Xiaoli Liu Xiaoli Liu 4*Ke Xu Ke Xu 5*Gang Tian Gang Tian 6*
  • 1 Southwest Medical University, Luzhou, Sichuan, China
  • 2 Western(Chongqing) Collaborative, Innovation, Center for Intelligent Diagnostics and Digital Medicine, Chongqing, China
  • 3 Ohio University, Athens, West Virginia, United States
  • 4 Xichong County People's Hospital, Nanchong, Anhui Province, China
  • 5 Chongqing General Hospital, Chongqing, Chongqing, China
  • 6 The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

The final, formatted version of the article will be published soon.

    In recent years, immunotherapy has made significant progress in cancer treatment, especially in malignant tumors that are difficult to cure with traditional therapies, showing unprecedented potential 1 . However, many patients do not exhibit durable responses to immunotherapy in clinical practice, and the issue of drug resistance remains prominent, making immune cell exhaustion one of the main barriers to current cancer immunotherapy 2 . Immune cell exhaustion is a complex process involving prolonged antigen stimulation, activation of immunosuppressive signals, and cellular metabolic dysregulation, ultimately leading to the dysfunction of effector T cells and other immune cells, thereby weakening the anti-tumor immune response

    Keywords: Immune cell exhaustion, Immunotherapy, Tumor Microenvironment, Single-cell sequencing (scRNA-seq), therapeutic targets

    Received: 13 Nov 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Chi, Jiang, Zhou, Wang, Yang, Luo, Liu, Xu and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Honghao Luo, Xichong County People's Hospital, Nanchong, 637200, Anhui Province, China
    Xiaoli Liu, Xichong County People's Hospital, Nanchong, 637200, Anhui Province, China
    Ke Xu, Chongqing General Hospital, Chongqing, 400081, Chongqing, China
    Gang Tian, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.