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CASE REPORT article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1519988

Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult

Provisionally accepted
Jing Ye Jing Ye Qian Yu Qian Yu Yan Chen Yan Chen Chunping Huang Chunping Huang *
  • Guangzhou Panyu Central Hospital, Guangzhou, China

The final, formatted version of the article will be published soon.

    Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting condition typically characterized by fever and lymphadenopathy. The exact etiology remains unclear but is suspected to be associated with viral infections and autoimmune responses. This report presents the case of a 32-year-old Chinese male who was admitted with recurrent high fever, lymphadenopathy, and hepatosplenomegaly. Initial treatment was ineffective, and a lymph node biopsy subsequently confirmed the diagnosis of KFD, with evidence of cytomegalovirus infection. Following treatment with corticosteroids, the patient's symptoms improved rapidly, and no relapse was observed during follow-up after discharge. This case highlights the diagnostic challenges of KFD, particularly in distinguishing it from lymphoma and systemic lupus erythematosus. Accurate and timely diagnosis is crucial to avoid unnecessary treatments, and long-term follow-up is recommended to monitor for potential disease progression.

    Keywords: Kikuchi-Fujimoto disease, lymphadenopathy, viral infections, Autoimmune, differential diagnosis

    Received: 30 Oct 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Ye, Yu, Chen and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunping Huang, Guangzhou Panyu Central Hospital, Guangzhou, China

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