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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1518431
This article is part of the Research Topic Community Series in Immune Responses Against Tumors - From the Bench to the Bedside: Volume II View all articles

Diagnostic value of multi-tumor-associated autoantibody expression in esophageal squamous cell carcinoma and correlation of clinical features

Provisionally accepted
Sihao Zhou Sihao Zhou 1Kejun Liu Kejun Liu 2*Yuyu Yang Yuyu Yang 1*Chuan Yuan Chuan Yuan 2*Yi Liu Yi Liu 1*Yi Liang Yi Liang 1*Wenhao Li Wenhao Li 1*Jingjing Zhang Jingjing Zhang 1Hongyu Ye Hongyu Ye 1*Sheng Gong Sheng Gong 3*Yingmeng Wu Yingmeng Wu 1*Weizhao Huang Weizhao Huang 1*
  • 1 Zhongshan People's Hospital (ZSPH), Zhongshan, Guangdong, China
  • 2 Guangdong Medical University, Zhanjiang, Guangdong, China
  • 3 Second Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Objective: This study aimed to investigate the diagnostic value of 7-TAAB and to evaluate the relationship between 7-TAAB and clinical features in ESCC, which can be used to guide clinical diagnosis and treatment and achieve its clinical value. Methods: (1) Blood specimens were collected from patients with ESCC who had not previously received antitumor therapy and those who had normal medical check-ups in the hospital during the same period. The concentrations of 7-TAAB in serum were determined by ELISA.The concentrations of 7-TAAB were compared between the ESCC and control groups, and the positive rate of 7-TAAB was calculated to determine the sensitivity, specificity, and accuracy of 7-TAAB. The diagnostic value of 7-TAAB was analyzed using the ROC curve. (2) The clinical data of patients with ESCC were collected and the correlation between the rate of 7-TAAB and clinical features was analyzed. (1) The serum levels and positivity rates of five antibodies were higher in the ESCC group than in the control group (P < 0.05) and the positive expression rate of the combined serum 7-TAAB in the ESCC group was significantly higher than that in the control group (P < 0.05). ( 2)The sensitivity of single antibody detection was 4.20%-17.65%, with a specificity of 96.49%-100%, and accuracy of 51.07%-57.94%. The sensitivity of 7-TAAB combined detection was 49.58%, the specificity was 92.98%, and the accuracy was 70.81%. (3) The ROC curve showed that the 7-TAAB combined test had a certain diagnostic value for ESCC and that its diagnostic efficacy was significantly higher than that of the single autoantibody tests. The diagnostic efficacy of the combined test with the remaining five antibodies was similar to that of the 7-TAAB combined test after eliminating the two antibodies with low expression rates. (4) Univariate analysis revealed significant differences in the positive expression rates of the 7-TAAB combination test in terms of age,hemoglobin,albumin,location,length,CN and CTNM (P < 0.05), and multivariate analysis revealed that age and CN were independent factors affecting antibody expression. The multi-tumor-associated autoantibody combination test not only has a good auxiliary diagnostic value but also closely correlates with the clinical features of ESCC.

    Keywords: esophageal squamous cell carcinoma, 7-tumor associated autoantibodies, Combination test, diagnostic value, Clinical features

    Received: 28 Oct 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Zhou, Liu, Yang, Yuan, Liu, Liang, Li, Zhang, Ye, Gong, Wu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Kejun Liu, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China
    Yuyu Yang, Zhongshan People's Hospital (ZSPH), Zhongshan, 528403, Guangdong, China
    Chuan Yuan, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China
    Yi Liu, Zhongshan People's Hospital (ZSPH), Zhongshan, 528403, Guangdong, China
    Yi Liang, Zhongshan People's Hospital (ZSPH), Zhongshan, 528403, Guangdong, China
    Wenhao Li, Zhongshan People's Hospital (ZSPH), Zhongshan, 528403, Guangdong, China
    Hongyu Ye, Zhongshan People's Hospital (ZSPH), Zhongshan, 528403, Guangdong, China
    Sheng Gong, Second Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China
    Yingmeng Wu, Zhongshan People's Hospital (ZSPH), Zhongshan, 528403, Guangdong, China
    Weizhao Huang, Zhongshan People's Hospital (ZSPH), Zhongshan, 528403, Guangdong, China

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