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CLINICAL TRIAL article

Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1518279
This article is part of the Research Topic Renal Fibrosis and Renal Transplantation View all articles

Assessing Donor Kidney Function: The Role of CIRBP in Predicting Delayed Graft Function Post-Transplant

Provisionally accepted
Qianghua Leng Qianghua Leng *Maolin Ma Maolin Ma Zuofu Tang Zuofu Tang Weichen Jiang Weichen Jiang Fei Han Fei Han *Zhengyu Huang Zhengyu Huang *
  • Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Introduction: Delayed graft function (DGF) shortens the survival time of transplanted kidneys and increases the risk of rejection. Current methods are inadequate in predicting DGF. More precise tools are required to assess kidney suitability for transplantation. Cold-inducible RNA-binding protein (CIRBP) expression has been linked to acute kidney injury, suggesting its potential as a new biomarker for transplanted kidney function. Methods: We included deceased donors and recipients who had undergone successful kidney transplantation between 2016 and 2019. Recipients and their paired donors are assigned to either the DGF or immediate graft function (IGF) group, based on the recipient's recovery of graft renal function. Donor plasma CIRBP levels were measured using an enzyme-linked immunosorbent assay kit to assess their relationships with DGF. Results: Donor plasma CIRBP concentrations in the DGF group were approximately twice as high as those in the IGF group (6.82 vs. 3.44; P<0.001). DGF occurred in all cases where CIRBP concentrations exceeded 7.92 ng/mL. Furthermore, univariate and multivariate analyses (odds ratio [OR]=1.660; P<0.001) confirmed that donor plasma CIRBP level was an independent risk factor for DGF. Additionally, higher CIRBP levels were associated with increased plasma creatinine at 6 months (R²=0.08; P<0.001), and survival analysis showed shorter kidney survival in recipients with DGF (P=0.002). Conclusions: This study demonstrated that donor plasma CIRBP levels can effectively predict the occurrence of DGF. CIRBP is a potential novel biomarker for evaluating transplanted kidney function.

    Keywords: Kidney Transplantation, cold-inducible RNA binding protein, Delayed Graft Function, Graft Survival, Acute Kidney Injury

    Received: 28 Oct 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Leng, Ma, Tang, Jiang, Han and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qianghua Leng, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
    Fei Han, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
    Zhengyu Huang, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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