Skip to main content

REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1517886
This article is part of the Research Topic Deciphering Macrophage Polarization/Transition in Human Inflammatory Disease and Cancer View all articles

Effects of Macrophages in OSCC Progression

Provisionally accepted
Xiaodan Dong Xiaodan Dong 1Chunling Dong Chunling Dong 2Bo Li Bo Li 3*
  • 1 Jilin University, Changchun, Hebei Province, China
  • 2 Department of Respiratory Medicine, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
  • 3 Hospital of Stomatology, Jilin University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Macrophages are crucial immune cells within the tumor microenvironment (TME), involved in regulating tumor proliferation, invasion, metastasis, ECM remodeling, angiogenesis, and immunosuppression. Although more and more experimental evidence and clinical data indicate that macrophages are involved in the onset and progression of oral squamous cell carcinoma (OSCC), the exact pathogenesis of OSCC associated with macrophages has not been fully elucidated. Enhanced knowledge of the molecular mechanisms involving macrophages in OSCC will aid in the creation of treatments targeted specifically at macrophages. This review outlines the pro-tumoral and anti-tumoral effects of macrophages in OSCC, emphasizing the interaction between OSCC cells and macrophages. It can provide theoretical basis for the establishment of complex regulatory network centered on macrophages and explore novel therapeutic strategies for OSCC.

    Keywords: oral squamous cell carcinoma, Macrophages, polarization, Interaction, loop

    Received: 27 Oct 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Dong, Dong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bo Li, Hospital of Stomatology, Jilin University, Changchun, 130021, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.