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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Systems Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1512519
This article is part of the Research Topic Unraveling Immune Metabolism: Single-Cell & Spatial Transcriptomics Illuminate Disease Dynamics View all 4 articles

Network Pharmacology and Multi-Omics Validation of the Jianpi-Yishen Formula in the Treatment of Chronic Kidney Disease

Provisionally accepted
Yuyan Li Yuyan Li 1Yueming Luo Yueming Luo 1Yilan Hu Yilan Hu 1,2Siting Li Siting Li 3Guandong Li Guandong Li 2Wanyangchuan Zhang Wanyangchuan Zhang 4Xiufen Gu Xiufen Gu 1Jianting Wang Jianting Wang 1Shunmin Li Shunmin Li 1Hong Cheng Hong Cheng 1*
  • 1 Shenzhen Traditional Chinese Medicine Hospital, Shenzhen ，Guangdong, China
  • 2 The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China
  • 3 Tongrentang first integrated Chinese and Western medicine hospital, Beijing, China
  • 4 Chongqing Red Cross Hospital, Jiangbei Qu, Chongqing, China

The final, formatted version of the article will be published soon.

    Objective: Chronic kidney disease (CKD) is a major global health problem. In clinical practice, the Chinese patent herbal medicine Jianpi-Yishen (JPYS) formula is commonly used to treat CKD. However, the molecular mechanisms by which JPYS targets and modulates the host immune response remain unclear.Methods: This study utilized network pharmacology, RNA sequencing (RNA-seq), and metabolic analyses using in vivo and in vitro models to investigate the impact of the JPYS formula on inflammation and the immune system. Specifically, the study focused on macrophage polarization and metabolic changes that may slow down the progression of CKD.Results: A total of 14,946 CKD-related targets were identified from the GeneCards and Online Mendelian Inheritance in Man (OMIM) databases through network pharmacology analyses. 227

    Keywords: Jianpi-Yishen formula, Chronic Kidney Disease, Network Pharmacology, Macrophage polarization, multi-omics

    Received: 16 Oct 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Li, Luo, Hu, Li, Li, Zhang, Gu, Wang, Li and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hong Cheng, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen ，Guangdong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.